COMMON

• High blood pressure
• Diarrhoea
• Nausea or vomiting
• Stomach pain
• Loss of appetite
• Weight loss
• Taste disturbance or loss of taste
• Sore mouth
• Headache
• Tumour pain
• Inadequate energy, weakness or tiredness
• Hair colour changes, unusual loss of hair or hair thinning
• Skin pigment loss
• Skin rash, peeling of the skin, skin burning, prickling, itching or tingling sensation
• Redness and swelling in the hands or soles of the feet
• Signs of decrease in albumin in the blood (weakness and exhaustion)
• Signs of low blood platelets (prolonged bleeding from guts, blood in urine or stools)
• Decrease in the number of white blood cells (muscle weakness, fatigue)
• Indigestion, bloating, flatulence
• Nose bleed
• Dry mouth or mouth ulcers
• Abnormal drowsiness
• Sleeping difficulties
• Signs of blood clot such as chest pain, shortness of breath, leg pain, If the clot is broken, it might move to your lungs
• Decreased effectiveness of heart at pumping the blood around the body (cardiac dysfunction)
• Slow heart beat
• Bleeding of mouth, rectum or lung
• Dizziness
• Blurred vision
• Hot flushes
• Fluid accumulation in face, hands, ankles, feet or eyelids that causes swelling
• Tingling, weak or numb hands, arms, legs and feet
• Nail disorders
• Sensation of coldness, with shivering
• Excessive sweating
• Dehydration
• Chest pain, joint, tendon pain, muscle pain and spasms
• Hoarseness
• Cough, coughing up blood
• Hiccups
• Lung collapse with air trapped between the chest and lung, which can cause shortness of breath (pneumothorax)
• Underactive thyroid gland

UNCOMMON

• Stroke (due to blood clot)
• Short term fall in the supply of blood to the brain (transient ischaemic attack)
• Obstruction of blood supply to part of the heart or heart attack (myocardial infarction)
• Partial obstruction of supply of blood to part of the heart (myocardial ischaemia)
• Blood clots associated with decrease in red blood cells and cells involved in clotting (thrombotic microangiopathy) which causes harm to brain and kidneys
• Signs of increased red blood cells (such as shortness of breath, fatigue, joint pain)
• Sharp chest pain or fast breathing (pulmonary embolism)
• Severe bleeding in digestive system (such as stomach, oesophagus or intestine), or in the kidneys, vagina and brain, hole (perforation) in stomach or intestine
• Heart rhythm disturbance (QT prolongation)
• Abnormal passages forming between parts of the intestine (fistula)
• Heavy or irregular menstrual periods
• Sharp and sudden increase in blood pressure (hypertensive crisis)
• Signs of pancreas inflammation (pancreatitis) such as abdominal pain
• Signs of liver inflammation (such as nausea, fatigue)
• Skin or whites of the eyes become yellow in colour (jaundice)
• Inflammation of abdominal cavity lining (peritonitis)
• Runny nose
• Itchy or inflamed rashes (flat or raised spots or blisters)
• Frequent bowel movements
• Increased skin sensitivity especially to sunlight
• Lowered feeling or sensitivity, especially in the skin
• Skin wound that do not heal (skin ulcer)

RARE

• Inflammation of the lung (pneumonitis)
• Enlarged and weakened blood vessel wall or blood vessel wall tear (aneurysms and artery dissections)

Stop taking VOTRIENT 200MG TABLET and consult with your doctor if you experience any of the following symptoms:

• Signs of swelling of the brain (loss of speech, change of vision, seizure (fits), confusion, high blood pressure)
• Signs of sudden and severe rise in blood pressure (severe chest pain, severe headache, blurred vision, confusion, nausea, vomiting, severe anxiety, shortness of breath, fainting)
• Signs of heart failure or heart attack (irregular or fast heartbeat, rapid fluttering of your heart, fainting, chest pain or pressure, painful arms, back, neck or jaw, leg swelling)
• Signs of stroke (one side of your body becomes weak and numb, difficulty talking, headache, dizziness)
• Signs of e severe bleeding in the digestive system or the lungs, kidneys, mouth, vagina and brain (black stools or stools with blood, urine with blood, painful stomach, coughing or vomiting up blood)
• Signs of a tear (perforation) stomach or intestinal wall or the development of an abnormal connection between two parts of your digestive tract (a fistula) (severe stomach pain, fever, hole formation (perforation) in the stomach, intestine or bowel from which pus is released which is bloody and has foul smell)
• Signs of liver problems (yellowing of your skin or the whites of your eyes (jaundice), dark urine, tiredness, loss of appetite, pain on the right side of your stomach area (abdomen), bruising easily)
• Signs of formation of a blood clot (sharp chest pain, rapid breathing, leg pain, swelling of arms and hands or legs and feet, bruising easily, high blood pressure, drowsiness, decrease in urine output)
• Signs of tumor lysis syndrome (fast breakdown of tumor cells) such as irregular heartbeat, seizures (fits), confusion, muscle cramps or spasms or decrease in urine output
• Signs of infection (cough, tiredness and body aches, pain while urination, fever, red, warm, swollen and painful cuts, scrapes or wounds)
• Signs of lung inflammation (shortness of breath or cough that will not go away)
• Decreased thyroid function (weight gain)
• Change in vision (blurry or impaired vision)